Bell Lab - Archaeal Chromosome Biology
The lab investigates the machineries that duplicate, express, organize and segregate the genome. To ensure viability, all cells must perform these processes in a timely and accurate manner. We exploit a multi- disciplinary range of cell and molecular biological, biochemical, genetic and structural approaches to determine the mechanistic and regulatory parameters that govern these essential cellular processes. Our work is driven by the evolutionary conservation of these fundamental machineries, allowing us to exploit archaea of the genus Sulfolobus as simple and robust model organisms.
Catherine Badel and Rachel Samson's study of chromosome architecture and evolution published at
PhD student Mark Greci's new study on primase published at
3C analyses of Sulfolobus published in and featured on the front cover.